Microsphere-mediated ultrasound represents a new treatment modality for RVO that addresses the underlying cause of the condition. Cerevast’s microspheres have a mean diameter of 1.1 – 3.3 microns and are comprised of a lipid shell and gas core. These microspheres can pass through the retinal vasculature due to their small size. Concomitantly administering ophthalmic ultrasound induces non-linear oscillations, or cavitation of the microspheres in the retinal veins thereby causing a release of energy and subsequent fluid motion in the region of the thrombus. This cavitation-induced energy of fluid motion is believed to be the underlying mechanism leading to clot lysis and reperfusion of retinal tissue. Pre-clinical and clinical studies of microsphere-mediated ophthalmic ultrasound have shown encouraging results as a non-invasive treatment for retinal vein occlusion leading to restored blood flow, reduction in intra-retinal hemorrhage volume and improved visual acuity scores.
Select Published Research Articles:
- Evaluation of Ultrasound-Assisted Thrombolysis Using Custom Liposomes in a Model of Retinal Vein Occlusion
- In Vivo Sonothrombolysis of Ear Marginal Vein of Rabbits Monitored with High Frequency Ultrasound Needle Transducer
- Effectiveness of Lipid Microbubbles and Ultrasound in Declotting Thrombosis
- A Pilot Clinical Study to Evaluate Microbubble-Assisted Ultrasound Thrombolysis in Retinal Vascular Occlusion (copy available upon request)